Biodistribution studies of boronophenylalanine in different types of skin melanoma.

Abstract

A study of the 10B-enriched Boronophenylalanine-fructose complex(10BPA-F) infusion procedure in potential BNCT patients, including three skin melanomas of extremities, was performed. 10B concentration in tumor(T), blood(B), skin(S) were measured to determine tumor/blood(T/B) and skin/blood(S/B) ratios. T/B ratio for three melanoma patients was in the range 1.48-3.82(average 2.56 ± 0.69). S/B ratio was in the range 0.81-1.99(average 1.29 ± 0.35). Results showed that T/B ratio of nodular metastasis melanoma was higher than superficial spreading melanoma. 10B concentration in skin was higher than blood, which was helpful to avoid over-dose in normal skin.

• Authors: Zizhu Zhang, Zhong Yong, Congjun Jin, Zewen Song, Shaihong Zhu, Tong Liu, Yang Chen, Yizheng Chong, Xinru Chen, Yongmao Zhou
• Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (Appl Radiat Isot) Vol. 163 Pg. 109215 (Sep 2020) ISSN: 1872-9800 [Electronic] England
• PMID: 32561053 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 Elsevier Ltd. All rights reserved.

Chemical References

• 4-boronophenylalanine-fructose
• Boron Compounds
• Fructose

Topics

• Aged
• Boron Compounds (metabolism)
• Fructose (analogs & derivatives, metabolism)
• Humans
• Male
• Melanoma (metabolism, pathology)
• Middle Aged
• Skin Neoplasms (metabolism, pathology)
• Tissue Distribution