Development of evocalcet for unmet needs among calcimimetic agents.

Abstract

INTRODUCTION:

The calcium-sensing receptor is an important treatment target for secondary hyperparathyroidism (SHPT) in patients undergoing dialysis. In addition to vitamin D receptor activator, cinacalcet has recently been widely used for SHPT management, and the significant suppression of parathyroid hormone (PTH) with better control of serum calcium and phosphorus has been reported. However, low adherence and insufficient dose escalation mainly due to frequent gastrointestinal adverse events, still remain as major issues. To overcome these unmet needs, we have developed a new oral calcimimetic agent evocalcet, which has recently been approved by the Pharmaceutical Affairs Act in Japan.

AREAS COVERED:

PubMed was searched from inception until April 2020 with the word evocalcet to summarize the development of this new calcimimetic agent, its pharmacokinetics, and the results of clinical trials, along with an overview of the differences among calcimimetic agents. This review also includes the management of SHPT with a focus on calcimimetics.

EXPERT OPINION:

Evocalcet evoked fewer gastrointestinal-related adverse events while suppressing PTH at a lower dose than cinacalcet. These data suggest evocalcet may contribute to better adherence and sufficient dose escalation in patients with SHPT. Whether or not evocalcet improves clinical outcomes remains to be elucidated.

• Authors: Naoto Hamano, Yuichi Endo, Takehisa Kawata, Masafumi Fukagawa
• Journal: Expert review of endocrinology & metabolism (Expert Rev Endocrinol Metab) Vol. 15 Issue 5 Pg. 299-310 (09 2020) ISSN: 1744-8417 [Electronic] England
• PMID: 32552012 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Calcimimetic Agents
• Naphthalenes
• Pyrrolidines
• Receptors, Calcium-Sensing
• Phosphorus
• evocalcet
• Calcium
• Cinacalcet

Topics

• Calcimimetic Agents (adverse effects, therapeutic use)
• Calcium (blood)
• Cinacalcet (adverse effects, therapeutic use)
• Gastrointestinal Diseases (chemically induced)
• Humans
• Hyperparathyroidism, Secondary (blood, drug therapy)
• Japan
• Naphthalenes (adverse effects, therapeutic use)
• Phosphorus (blood)
• Pyrrolidines (adverse effects, therapeutic use)
• Receptors, Calcium-Sensing (drug effects)
• Renal Dialysis
• Renal Insufficiency, Chronic (drug therapy)