Association of STAT4 Gene Rs7574865, Rs10168266 Polymorphisms and Systemic Lupus Erythematosus Susceptibility: A Meta-analysis.

Abstract

Association of signal transducer and activator of transcription 4 (STAT4) gene rs7574865, rs10168266 polymorphisms with systemic lupus erythematosus (SLE) risk remains unclear. A meta-analysis was conducted on the correlation between rs7574865, rs10168266 polymorphisms and SLE. Twenty-six studies were recruited in our study (17,389 patients and 29,273 controls). For rs7574865, results showed significant associations between T allele and SLE susceptibility in overall population, Asians and Europeans (OR=1.557, 95%CI: 1.505-1.611, P<0.001; OR=1.557, 95%CI: 1.498-1.661, P<0.001; OR=1.548, 95%CI: 1.474-1.625, P<0.001). Significant associations of genotypes TT, GT, TT+TG and SLE risk were observed in general subjects, Asians and Europeans (all P<0.001). Regarding rs10168266, increased T allele frequencies were detected in overall SLE cases and those from Asian origin (OR=1.532, 95%CI: 1.440-1.631, P<0.001; OR=1.575, 95%CI: 1.445-1.717, P<0.001). The overall data showed that TT genotype, CT genotype and TT+CT genotype were significantly correlated with SLE (all P < 0.001). In conclusion, the present study verified strong association of STAT4 gene rs7574865, rs10168266 polymorphisms and SLE susceptibility.

• Authors: Jia-Min Wang, Wang-Dong Xu, An-Fang Huang
• Journal: Immunological investigations (Immunol Invest) Vol. 50 Issue 2-3 Pg. 282-294 (Feb 2021) ISSN: 1532-4311 [Electronic] England
• PMID: 32429712 (Publication Type: Journal Article, Meta-Analysis)

Chemical References

• STAT4 Transcription Factor
• STAT4 protein, human

Topics

• Gene Frequency
• Genetic Association Studies
• Genetic Predisposition to Disease
• Genotype
• Humans
• Lupus Erythematosus, Systemic (genetics)
• Polymorphism, Single Nucleotide
• Risk
• STAT4 Transcription Factor (genetics)