Research Progress on lncRNA Functions and Mechanisms in Pituitary Adenomas.

Abstract

Despite being the most common human neuroendocrine tumor, the pathogenesis of pituitary adenomas (PAs) is still unclear. Long non-coding RNA (lncRNA) is involved in a variety of physiological and pathological processes, and has been shown to play a key role in the process of tumor instigation and development by affecting the proliferation, migration, invasiveness, and metastasis of tumor cells. Therefore, lncRNAs may be used as diagnostic and prognostic markers of tumors. In this paper, the effect of lncRNA on the onset and progression of PAs is reviewed so as to provide a profound understanding of its pathogenesis and clinical reference for the early diagnosis of PAs.

• Authors: Qiu Du, De-Shan Yao, You-Wei Wang, Cheng Cheng
• Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme (Horm Metab Res) Vol. 52 Issue 5 Pg. 280-288 (May 2020) ISSN: 1439-4286 [Electronic] Germany
• PMID: 32403143 (Publication Type: Journal Article, Review)
• Copyright: © Georg Thieme Verlag KG Stuttgart · New York.

Chemical References

• RNA, Long Noncoding

Topics

• Adenoma (genetics)
• Animals
• Biomedical Research
• Gene Expression Regulation, Neoplastic
• Humans
• Pituitary Neoplasms (genetics)
• RNA, Long Noncoding (genetics, metabolism)