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A metal-free aromative cascade for the synthesis of diverse heterocycles.

Abstract
A metal-free aromative cascade has been developed for the synthesis of diverse heterocycles from readily accessible hydroxy/aminochalcones and acid/alkyl halides. The cascade being by a base-mediated intramolecular aldol cyclization/dehydration sequence to provide a triene, which sets the stage for a 6π-electrocyclization/oxidative aromatization to access diverse heterocyclic scaffolds.
AuthorsSteven C Schlitzer, Dhanarajan Arunprasath, Katelyn G Stevens, Indrajeet Sharma
JournalOrganic chemistry frontiers : an international journal of organic chemistry (Org Chem Front) Vol. 7 Issue 7 Pg. 913-918 (Apr 07 2020) ISSN: 2052-4110 [Print] England
PMID32368346 (Publication Type: Journal Article)

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