Nanozyme-catalyzed oxygen release from calcium peroxide nanoparticles for accelerated hypoxia relief and image-guided super-efficient photodynamic therapy.

Abstract

Hypoxia within solid tumors severely limits the efficacy of photodynamic therapy (PDT). Biocompatible calcium peroxide nanoparticles (CaO2 NPs) have superior oxygen generating capacity for hypoxia relief but the relatively slow release of O2 from CaO2 NPs hampers the PDT efficacy enhancement. Herein, manganese dioxide (MnO2) is applied as a nanozyme to facilitate O2 release from CaO2 NPs. It is disclosed that the accelerated O2 release ensures a rapid and efficient amplification of the O2 level for an increased cytotoxic singlet oxygen production with chlorin e6 and leads to a down-regulated hypoxia-responsive protein expression, which eventually translates to a super-efficient PDT as evidenced by the complete eradication of mice bearing subcutaneous 4T1 tumors. Meanwhile, MnO2 imparts an MR T1 imaging modality for tumor detection and treatment planning. These findings signify the essential role of accelerated and efficient hypoxia relief in PDT efficacy enhancement and provide an effective paradigm to overcome hypoxia-associated resistance for an enhanced therapeutic efficacy.

• Authors: Yuping Hu, Xuechun Wang, Peng Zhao, Hao Wang, Wei Gu, Ling Ye
• Journal: Biomaterials science (Biomater Sci) Vol. 8 Issue 10 Pg. 2931-2938 (May 19 2020) ISSN: 2047-4849 [Electronic] England
• PMID: 32314771 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Biocompatible Materials
• Fluorescent Dyes
• Manganese Compounds
• Oxides
• Peroxides
• calcium peroxide
• Oxygen
• manganese dioxide

Topics

• Animals
• Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
• Biocompatible Materials (chemical synthesis, chemistry, pharmacology)
• Breast Neoplasms (drug therapy, metabolism, pathology)
• Catalysis
• Cell Hypoxia (drug effects)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Female
• Fluorescent Dyes (chemistry)
• Mammary Neoplasms, Experimental (drug therapy, metabolism, pathology)
• Manganese Compounds (chemical synthesis, chemistry, pharmacology)
• Mice
• Nanoparticles (chemistry)
• Oxides (chemical synthesis, chemistry, pharmacology)
• Oxygen (analysis, metabolism)
• Peroxides (chemistry, metabolism)
• Photochemotherapy