Abstract |
Two-dimensional nanomaterial-based photothermal therapy (PTT) is currently under intensive investigation as a promising approach toward curative cancer treatment. However, high toxicity, moderate efficacy, and low uniformity in shape remain critical unresolved issues that hamper their clinical application. Thus, there is an urgent need for developing versatile nanomaterials to meet clinical expectations. To achieve this goal, we developed a stable, highly uniform in size, and nontoxic nanomaterials made of tellurium- selenium (TeSe)-based lateral heterojunction. Systemic delivery of TeSe nanoparticles in mice showed highly specific accumulation in tumors relative to other healthy tissues. Upon exposure to light, TeSe nanoparticles nearly completely eradicated lung cancer and hepatocellular carcinoma in preclinical models. Consistent with tumor suppression, PTT altered the tumor microenvironment and induced immense cancer cell apoptosis. Together, our findings demonstrate an exciting and promising PTT-based approach for cancer eradication.
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Authors | Shiyou Chen, Chenyang Xing, Dazhou Huang, Chuanhong Zhou, Bo Ding, Ziheng Guo, Zhengchun Peng, Dou Wang, Xi Zhu, Shuzhen Liu, Zhen Cai, Jieyu Wu, Jiaqi Zhao, Zongze Wu, Yuhua Zhang, Chaoying Wei, Qiaoting Yan, Hongzhong Wang, Dianyuan Fan, Liping Liu, Han Zhang, Yihai Cao |
Journal | Science advances
(Sci Adv)
Vol. 6
Issue 15
Pg. eaay6825
(04 2020)
ISSN: 2375-2548 [Electronic] United States |
PMID | 32284997
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). |
Chemical References |
- Antineoplastic Agents
- Biomarkers
- Drug Carriers
- Selenium
- Tellurium
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Topics |
- Animals
- Antineoplastic Agents
(administration & dosage, pharmacokinetics)
- Biomarkers
- Cell Line, Tumor
- Chemical Phenomena
- Disease Models, Animal
- Drug Carriers
(chemistry)
- Fluorescent Antibody Technique
- Humans
- Metal Nanoparticles
(chemistry, ultrastructure)
- Mice
- Selenium
(chemistry)
- Tellurium
(chemistry)
- Xenograft Model Antitumor Assays
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