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Patients with mutations of the Thyroid hormone beta-receptor show an ADHD-like phenotype for performance monitoring: an electrophysiological study.

Abstract
Resistance to thyroid hormone beta (RTHβ) is a syndrome of reduced responsiveness of peripheral tissue to thyroid hormone, caused by mutations in the thyroid hormone receptor beta (THRB). Its cognitive phenotype has been reported to be similar to attention deficit hyperactivity disorder (ADHD). This study used electrophysiological biomarkers of performance monitoring in RTHβ to contribute further evidence on its phenotypical similarity to ADHD. Twenty-one participants with RTHβ aged 18-67 years and 21 matched healthy controls performed a modified flanker task during EEG recording. The RTHβ and control groups were compared on behavioural measures and components of event related potentials (ERPs), i.e. the error related negativity (ERN), the error positivity (Pe) and P3 component. There were no significant group differences with regard to behaviour. RTHβ subjects displayed significantly reduced ERN and Pe amplitudes compared to the controls in the response-locked ERPs. In addition, we observed reduced P3 amplitudes in both congruent and incongruent trials, as well as prolonged P3 latencies in RTHβ subjects in the stimulus-locked ERPs. Our findings reveal alterations in error detection and performance monitoring of RTHβ patients, likely indicating reduced error awareness. The electrophysiological phenotype of RTHß subjects with regard to action monitoring is indistinguishable from ADHD.
AuthorsJan Uter, Marcus Heldmann, Berenike Rogge, Martina Obst, Julia Steinhardt, Georg Brabant, Carla Moran, Krishna Chatterjee, Thomas F Münte
JournalNeuroImage. Clinical (Neuroimage Clin) Vol. 26 Pg. 102250 ( 2020) ISSN: 2213-1582 [Electronic] Netherlands
PMID32217468 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
Chemical References
  • Thyroid Hormone Receptors beta
Topics
  • Adolescent
  • Adult
  • Aged
  • Attention Deficit Disorder with Hyperactivity (genetics, physiopathology)
  • Electroencephalography
  • Evoked Potentials (physiology)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mutation
  • Phenotype
  • Thyroid Hormone Receptors beta (genetics)
  • Thyroid Hormone Resistance Syndrome (complications, genetics)
  • Young Adult

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