[A Case of Curatively Resected Locally Recurrent Rectal Mucinous Adenocarcinoma Followed by Preoperative Chemoradiotherapy].

Abstract

A 60s man was diagnosed with rectal cancer and underwent low anterior resection of the rectum. The pathological diagnosis was mucinous adenocarcinoma, pT3(SS), pN0, pM0, pStage Ⅱ. Two years after the primary surgery, contrast-enhanced CT showed local recurrence on the oral side of the anastomosis. As the tumor had invaded the left seminal vesicle and coccygeus muscle, neoadjuvant chemoradiotherapy(NACRT)(S-1 80mg/m / 2 plus 45 Gy/25 Fr)was performed. After NACRT, abdominoperineal resection, including the left seminal vesicle, coccygeus muscle, and coccygeal bone, was performed. Pathological examination showed a histological response of Grade 2 and that R0 resection was achieved. Although the only radical treatment of locally recurrent rectal cancer is R0 resection, we performed R0 resection with Grade 2 histological response to NACRT.

• Authors: Keisuke Sato, Hideaki Karasawa, Taiki Kajiwara, Hideyuki Suzuki, Atsushi Kohyama, Kazuhiro Watanabe, Shinobu Ohnuma, Takanori Ishida, Takashi Kamei, Takeshi Naitoh, Michiaki Unno
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 46 Issue 13 Pg. 2440-2442 (Dec 2019) ISSN: 0385-0684 [Print] Japan
• PMID: 32156958 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antimetabolites, Antineoplastic
• Drug Combinations
• S 1 (combination)
• Tegafur
• Oxonic Acid

Topics

• Adenocarcinoma, Mucinous (therapy)
• Antimetabolites, Antineoplastic (therapeutic use)
• Chemoradiotherapy
• Drug Combinations
• Humans
• Male
• Neoadjuvant Therapy
• Neoplasm Recurrence, Local
• Neoplasm Staging
• Oxonic Acid (therapeutic use)
• Rectal Neoplasms (therapy)
• Tegafur (therapeutic use)
• Treatment Outcome