Abstract | BACKGROUND: Air pollution has been shown to be associated with blood lipid levels. However, studies on long-term ambient particulate matter with aerodynamic diameter ≤1 μm (PM1) exposure in high-exposure areas are still limited. This study aimed to explore the associations among long-term PM1 exposure, blood lipids and dyslipidemias. METHODS: Baseline data of The Henan Rural Cohort study was used in present study, including a total of 39,259 participants aged from 18 to 79 years. Daily levels of PM1 were estimated by a spatiotemporal model using ground-level measurements of PM1, satellite remote sensing data and other predictors, according to participants' home addresses. Individual exposure to PM1 was the 3-year average before baseline investigation. Linear regression and logistic regression models were applied to examine the associations among PM1, blood lipids ((total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol ( LDL-C)), and prevalence of dyslipidemias. RESULTS: The 3-year concentration of PM1 was 55.7 ± 2.1 μg/m3. Each 1 μg/m3 increment of PM1 was associated with an increase of 0.21% (95% confidence interval (CI): 0.11%-0.31%) in TC and 0.75% (95% CI: 0.61%-0.90%) in LDL-C, while decrease of 2.68% (95% CI: 2.43%-2.93%) in TG and 0.47% (95% CI: 0.35%-0.59%) in HDL-C. Each 1 μg/m3 increase in PM1 was associated with 6% (95% CI: 4%-8%), 3% (95% CI: 2%-5%) and 5% (95% CI: 3%-7%) higher risks of hypercholesterolemia, hyperbetalipoproteinemia and hypoalphalipoproteinemia. Sex, age and BMI statistically modified the associations between PM1 with blood lipid levels and dyslipidemias. CONCLUSIONS: Higher PM1 exposure was associated with adverse changes of blood lipid levels and dyslipidemias. Males, older and overweight participants were susceptive to the adverse effects of PM1.
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Authors | Shuyuan Mao, Shanshan Li, Chongjian Wang, Yisi Liu, Na Li, Feifei Liu, Shuqiong Huang, Suyang Liu, Yuanan Lu, Zhenxing Mao, Wenqian Huo, Gongbo Chen, Hao Xiang, Yuming Guo |
Journal | Environment international
(Environ Int)
Vol. 138
Pg. 105637
(05 2020)
ISSN: 1873-6750 [Electronic] Netherlands |
PMID | 32155508
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved. |
Chemical References |
- Air Pollutants
- Lipids
- Particulate Matter
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Topics |
- Adolescent
- Adult
- Aged
- Air Pollutants
(analysis)
- China
(epidemiology)
- Cohort Studies
- Dyslipidemias
(epidemiology)
- Humans
- Lipids
- Male
- Middle Aged
- Particulate Matter
(analysis)
- Rural Population
- Young Adult
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