Triple-negative breast cancer (TNBC) is a type of malignant and heterogeneous
tumor in premenopausal females with ineffective therapeutic targets.
IL-8 is one of the earliest discovered chemotaxis
cytokines which expression is closely related to the progress of various
cancers. Previous studies showed that
IL-8 determines the prognosis of TNBC patients, nevertheless how
IL-8 influences the progress of TNBC is unclear. In our studies, we discovered that overexpression of
IL-8 promotes TNBC cells (TNBCs) migration and
tumor growth via the PI3K-Akt and MAPK signaling pathway. Cell-cycle of TNBCs arrest at S phase by overexpression of
IL-8, however, there is no significant variation on the cell viability and cell apoptosis of TNBCs. Besides, overexpression of
IL-8 result in the downregulation of
E-cadherin and the upregulation of
Cyclin B1 in MDA-MB-231 cells. Taken together, our results suggest that
IL-8 performs a crucial role in the progress of TNBC, and it could be a novel therapeutic target of TNBC.