Effects of Gaba Derivatives on Anxious and Compulsive Behavior in Offspring of Rats with Experimental Preeclampsia.

Abstract

We studied the effects of GABA derivatives on anxious and compulsive behavior of progeny of rats with experimental preeclampsia provoked by replacement of drinking water for 1.8% NaCl solution from the first day of pregnancy to delivery. In comparison with progeny of health rats, the offspring of dams with complicated pregnancy demonstrated high level of anxiety and the development of obsessive-compulsive disorder both at the early (40 and 70 days) and late (6 and 12 months) stages of ontogeny. GABA derivatives succicard, salifen, and phenibut reduced symptoms of experimental preeclampsia in offspring of various age by decreasing the level of anxiety and reducing compulsive behavior. The efficacy of the examined derivatives was similar to that of the reference drug Pantogam.

• Authors: E A Muzyko, G A Tkacheva, V N Perfilova, L S Matvienko, L V Naumenko, O S Vasil'eva, I N Tyurenkov
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 168 Issue 4 Pg. 457-464 (Feb 2020) ISSN: 1573-8221 [Electronic] United States
• PMID: 32146627 (Publication Type: Journal Article)

Chemical References

• Anti-Anxiety Agents
• GABA Agonists
• Tranquilizing Agents
• pantogab
• Pantothenic Acid
• Sodium Chloride
• gamma-Aminobutyric Acid
• 4-amino-3-phenylbutyric acid

Topics

• Animals
• Animals, Outbred Strains
• Anti-Anxiety Agents (pharmacology)
• Anxiety (chemically induced, drug therapy, metabolism, physiopathology)
• Behavior, Animal (drug effects)
• Female
• GABA Agonists (pharmacology)
• Male
• Obsessive-Compulsive Disorder (chemically induced, drug therapy, metabolism, physiopathology)
• Pantothenic Acid (analogs & derivatives, pharmacology)
• Pre-Eclampsia (chemically induced, drug therapy, metabolism, physiopathology)
• Pregnancy
• Prenatal Exposure Delayed Effects (chemically induced, drug therapy, metabolism, physiopathology)
• Rats
• Sodium Chloride (administration & dosage)
• Tranquilizing Agents (pharmacology)
• gamma-Aminobutyric Acid (analogs & derivatives, pharmacology)