Biodegradable Biliary Stents for Percutaneous Treatment of Post-liver Transplantation Refractory Benign Biliary Anastomotic Strictures.

Abstract

PURPOSE:

The aim of this study was to evaluate the safety and the effectiveness of polydioxanone-made biodegradable biliary stent placement for the treatment of post-transplant benign, refractory biliary anastomotic strictures.

MATERIALS AND METHODS:

This was a retrospective observational study on all adult liver transplant recipients who developed a clinically significant anastomotic stricture between January 2014 and June 2017. Percutaneous transhepatic cholangioplasty with balloon dilation was performed as therapeutic approach in selected patients after multidisciplinary evaluation. Refractory strictures (defined as stricture persistence after two interventional procedures) were managed with placement of polydioxanone-made biodegradable biliary stent (SX-Ella biliary stent, Czech Republic). Patency of the common bile duct was calculated using Kaplan-Meier analysis.

RESULTS:

Eighteen adult liver transplant recipients who developed a refractory biliary anastomotic stricture [males/females 13/5, median (IQR) 58.2 (9.3) years] underwent biodegradable biliary stent placement after 10.4 (32) months from liver transplantation. All procedures except one were uneventful. After a median (IQR) follow-up time of 27.2 (22) months, complete resolution of anastomotic stricture was achieved in 72% of patients, with significant improvement on liver enzymes.

CONCLUSIONS:

Polydioxanone-made biodegradable biliary stent might be a safe and effective therapeutic option for the difficult-to-treat benign biliary anastomotic stricture after liver transplantation.

• Authors: Michele Battistel, Marco Senzolo, Alberto Ferrarese, Amalia Lupi, Umberto Cillo, Patrizia Boccagni, Giacomo Zanus, Roberto Stramare, Emilio Quaia, Patrizia Burra, Giulio Barbiero
• Journal: Cardiovascular and interventional radiology (Cardiovasc Intervent Radiol) Vol. 43 Issue 5 Pg. 749-755 (May 2020) ISSN: 1432-086X [Electronic] United States
• PMID: 32133551 (Publication Type: Journal Article, Observational Study)

Topics

• Absorbable Implants
• Anastomosis, Surgical
• Common Bile Duct (physiopathology, surgery)
• Constriction, Pathologic (surgery)
• Female
• Humans
• Liver Transplantation
• Male
• Middle Aged
• Retrospective Studies
• Stents
• Treatment Outcome