Effectiveness of dupilumab for the treatment of nummular eczema phenotype of atopic dermatitis in adults.

Abstract

Nummular eczema (NE) is currently considered as one of the clinical phenotypes of atopic dermatitis (AD) of the adult. In this multicentre study, 30 adult patients (age ≥ 18 years) affected with nummular-like AD were treated with dupilumab, a monoclonal antibody against the receptor for interleukin(IL)-4 and IL-13. The evaluation of the results after 16 weeks of treatment showed a significant improvement of the disease, as demonstrated by reduction in Eczema Area Severity Score (EASI), visual analogue score (VAS) of pruritus, and Dermatology Life Quality Index (DLQI) scores. Conjunctivitis in one patient was the only side effect. In conclusion, dupilumab seems to be an effective and safe treatment in NE phenotype of AD of the adult.

• Authors: Cataldo Patruno, Luca Stingeni, Katharina Hansel, Silvia Mariel Ferrucci, Simona Tavecchio, Gabriella Fabbrocini, Steven Paul Nisticò, Caterina Foti, Serena De Prezzo, Maddalena Napolitano
• Journal: Dermatologic therapy (Dermatol Ther) Vol. 33 Issue 3 Pg. e13290 (05 2020) ISSN: 1529-8019 [Electronic] United States
• PMID: 32125741 (Publication Type: Journal Article, Multicenter Study)
• Copyright: © 2020 Wiley Periodicals LLC.

Chemical References

• Antibodies, Monoclonal, Humanized
• dupilumab

Topics

• Adolescent
• Adult
• Antibodies, Monoclonal, Humanized
• Dermatitis, Atopic (diagnosis, drug therapy)
• Eczema
• Humans
• Phenotype
• Severity of Illness Index