FibroAtlas: A Database for the Exploration of Fibrotic Diseases and Their Genes.

Abstract

BACKGROUND:

Fibrosis is a highly dynamic process caused by prolonged injury, deregulation of the normal processes of wound healing, and extensive deposition of extracellular matrix (ECM) proteins. During fibrosis process, multiple genes interact with environmental factors. Over recent decades, tons of fibrosis-related genes have been identified to shed light on the particular clinical manifestations of this complex process. However, the genetics information about fibrosis is dispersed in lots of extensive literature.

METHODS:

We extracted data from literature abstracts in PubMed by text mining, and manually curated the literature and identified the evidence sentences.

RESULTS:

We presented FibroAtlas, which included 1,439 well-annotated fibrosis-associated genes. FibroAtlas 1.0 is the first attempt to build a nonredundant and comprehensive catalog of fibrosis-related genes with supporting evidence derived from curated published literature and allows us to have an overview of human fibrosis-related genes.

• Authors: Jinying Liu, Dezhi Sun, Jiale Liu, Hao Xu, Yuan Liu, Yang Li, Lihong Diao, Xun Wang, Dan Wang, Lei Tian, Huimin Zhang, Zhongyang Liu, Weiquan Ren, Fuchu He, Dong Li, Shuzhen Guo
• Journal: Cardiology research and practice (Cardiol Res Pract) Vol. 2019 Pg. 4237285 ( 2019) ISSN: 2090-8016 [Print] United States
• PMID: 32082621 (Publication Type: Journal Article)
• Copyright: Copyright © 2019 Jinying Liu et al.