[Neuroprotection and Regeneration in the Central Nervous System].

Abstract

The development of neuroprotective and regenerative therapies in the central nervous system (CNS) poses a major challenge in clinical and basic research. In contrast to the peripheral nervous system, which has a comparatively high intrinsic regenerative capacity, this characteristic is poorly developed in the adult CNS. In this review, some basic growth mechanisms of CNS neurons will be highlighted, as well as factors that prevent successful regeneration after injury. Primarily in the context of glaucoma, preclinical and clinical studies are presented which can improve the understanding of neurodegenerative processes in the optical system and thus provide the basis for current and future therapeutic strategies.

• Authors: Markus Höltje, Francesco Boato
• Journal: Klinische Monatsblatter fur Augenheilkunde (Klin Monbl Augenheilkd) Vol. 237 Issue 2 Pg. 128-132 (Feb 2020) ISSN: 1439-3999 [Electronic] Germany
• Vernacular Title: Neuroprotektion und Regeneration im Zentralnervensystem.
• PMID: 32040975 (Publication Type: Journal Article, Review)
• Copyright: Georg Thieme Verlag KG Stuttgart · New York.

Topics

• Central Nervous System
• Glaucoma
• Humans
• Nerve Regeneration
• Neurons
• Neuroprotection