Rapid improvement of obsessive-compulsive disorder associated with schizophrenia with cariprazine add-on in a subject under paliperidone long-acting injection: a case report.

Abstract

Obsessive-compulsive disorder is often associated with schizophrenia and may represent a significant challenge in the treatment as this comorbidity may not respond properly to antipsychotic medication and usually require a pharmacological and psychotherapeutic add-on. In the present case report, we present the case of a 26-year-old male blue-collar subject who developed obsessive-compulsive disorder after a year of complete remission of schizophrenia symptoms under paliperidone long-acting injection that rapidly resolved after low-dosage cariprazine add-on. No adverse effects were reported due to cariprazine- paliperidone long-acting injection combination.

• Authors: Domenico De Berardis, Federica Vellante, Michele Fornaro, Laura Orsolini, Alessandro Valchera, Gaia Baroni, Yong-Ku Kim, Giovanni Martinotti, Massimo Di Giannantonio
• Journal: International clinical psychopharmacology (Int Clin Psychopharmacol) Vol. 35 Issue 2 Pg. 113-118 (03 2020) ISSN: 1473-5857 [Electronic] England
• PMID: 32004167 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antipsychotic Agents
• Delayed-Action Preparations
• Piperazines
• cariprazine
• Paliperidone Palmitate

Topics

• Adult
• Antipsychotic Agents
• Comorbidity
• Delayed-Action Preparations (therapeutic use)
• Drug Therapy, Combination
• Humans
• Injections, Intramuscular
• Male
• Obsessive-Compulsive Disorder (drug therapy, epidemiology)
• Paliperidone Palmitate (administration & dosage, therapeutic use)
• Piperazines (therapeutic use)
• Schizophrenia (epidemiology)