Abstract | RATIONALE: PATIENT CONCERNS: DIAGNOSIS: Contrast-enhanced computed tomography (CT) revealed the stenosis of femoral arteries and increased levels of C-reactive protein (CRP), and serum amyloid A (SAA) were noted in both patients. According to European league against rheumatism consensus criteria for the diagnosis of TA was confirmed in both patients. INTERVENTIONS: OUTCOMES: These treatments improved claudication symptoms. Follow-up imaging by enhanced CT revealed restoration of advanced stenosis of the femoral arteries in both patients. They achieved normalization of levels of the acute-phase reactants CRP and SAA. Serum levels of interleukin-6 were increased transiently after TCZ injection, but declined to within normal ranges at 12 weeks. LESSONS: Juvenile patients with TA presenting with advanced stenosis of the femoral arteries are not rare. The clinical courses of our patients suggested the beneficial effects of TCZ against the progressive vascular stenosis observed in refractory TA.
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Authors | Tomoyuki Asano, Shuzo Sato, Jumpei Temmoku, Yuya Fujita, Makiko Yashiro Furuya, Naoki Matsuoka, Hiroko Kobayashi, Eiji Suzuki, Hiroshi Watanabe, Kiyoshi Migita |
Journal | Medicine
(Medicine (Baltimore))
Vol. 99
Issue 4
Pg. e18890
(Jan 2020)
ISSN: 1536-5964 [Electronic] United States |
PMID | 31977898
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antibodies, Monoclonal, Humanized
- IL6 protein, human
- Interleukin-6
- tocilizumab
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Topics |
- Adolescent
- Antibodies, Monoclonal, Humanized
(therapeutic use)
- Constriction, Pathologic
(etiology)
- Female
- Femoral Artery
(diagnostic imaging, physiopathology)
- Humans
- Interleukin-6
(blood)
- Intermittent Claudication
(etiology)
- Leg
- Takayasu Arteritis
(complications, drug therapy, etiology, physiopathology)
- Treatment Outcome
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