Antidiabetic and antioxidative efficacy of the constituents present in the fraction solvents of Curcuma amada rhizomes: An experimental study on the diabetic rat model.
|
| Abstract |
All over the world, the prevalence of diabetes mellitus is increasing. The main goal of this experiment was to identify the most effective fraction of aqueous-methanol extract of Curcuma amada rhizome for its antidiabetic and antioxidative properties. The fractions (n-hexane or chloroform or ethyl-acetate or n-butanol) of aqueous-methanol extract were administered to the streptozotocin-induced diabetic groups at a dose of 10 mg/100 g body weight/day for 4 weeks. The antidiabetic and antioxidative efficacies of the fractions on glycemic, enzymatic, genomic, and histological sensors and pancreatic β-cells population and general toxicity were assessed. After the fraction treatment, out of the fraction used, the significant recovery in most sensors was noted at the ethyl-acetate fraction in glycemic, enzymatic, genomic, β cells population, diameter of the pancreatic islet and toxicity level. In conclusion, it may be stated that the ethyl-acetate fraction of C. amada was the most effective solvent in this study. PRACTICAL APPLICATIONS: The ethyl-acetate fraction of aqueous-methanol extract of Curcuma amada has antidiabetic property, it gives a clue to the herbal medicine manufacturing company to produce phytotherapeutic drugs to cure the complication related to diabetes.
|
|---|---|
| Authors | Dipanwita Mitra, Adrija Tripathy, Debidas Ghosh |
| Journal | Journal of food biochemistry (J Food Biochem) Vol. 44 Issue 3 Pg. e13154 (03 2020) ISSN: 1745-4514 [Electronic] United States |
| PMID | 31970789 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
| Copyright | © 2020 Wiley Periodicals, Inc. |
| Chemical References |
|
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research graph!