Abstract | OBJECTIVE: METHODS: Data from patients who were treated for hydatidiform moles between 1995 and 2016 were retrospectively reviewed. Patient age, gravidity, parity, abortion history, gestational age, pretreatment beta- human chorionic gonadotropin (HCG), previous molar pregnancy, clinical symptoms, enlarged uterus, theca lutein cyst, type of GTN, World Health Organization risk score, chemotherapy, and mode of delivery were recorded. Hazard ratios (HR) and 95% confidence intervals (CI) for variables associated with the occurrence of post-molar GTN and invasive mole were estimated by univariate and multivariate Cox proportional hazards models. RESULTS: From 1995 to 2016, 182 patients were diagnosed with molar pregnancy and underwent treatment. Patients with previous C/S (C/S group) had higher age (37.0 vs 32.8. p = 0.004), gravidity (3.1 vs 2.0, p < 0.001), and parity (1.6 vs 0.9, p < 0.001) than patients without previous C/S (non-C/S group). Post-molar GTN (43.5 vs 26.5%, p < 0.001), invasive mole (21.7 vs 3.7%, p < 0.001), hysterectomy (28.3 vs 6.6%, p < 0.001), and chemotherapy (45.7 vs 28.7%, p = 0.03) were more frequent in the C/S group. In multivariate analysis, independent risk factors for post-molar GTN were previous C/S (HR 5.1, 95% CI 2.1-12.7), abortion history (HR 6.3, 95% CI 2.5-15.6), and pretreatment β-hCG (HR 1.3, 95% CI 1.1-1.6). CONCLUSIONS:
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Authors | Hyun-Woong Cho, Yung-Taek Ouh, Kyung-Jin Min, Nak Woo Lee, Sanghoon Lee, Jae Yun Song, Jin Hwa Hong, Jae Kwan Lee |
Journal | Gynecologic oncology
(Gynecol Oncol)
Vol. 156
Issue 3
Pg. 606-610
(03 2020)
ISSN: 1095-6859 [Electronic] United States |
PMID | 31954533
(Publication Type: Journal Article)
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Copyright | Copyright © 2019. Published by Elsevier Inc. |
Chemical References |
- Chorionic Gonadotropin, beta Subunit, Human
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Topics |
- Adult
- Cesarean Section
(statistics & numerical data)
- Chorionic Gonadotropin, beta Subunit, Human
(blood)
- Female
- Gestational Trophoblastic Disease
(blood, drug therapy, epidemiology, surgery)
- Humans
- Hydatidiform Mole
(blood, drug therapy, epidemiology, surgery)
- Multivariate Analysis
- Parity
- Pregnancy
- Risk
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