Vitamin D status in children with leukemia, its predictors, and association with outcome.

Abstract

BACKGROUND:

Children and adolescents with leukemia are potentially at high risk of vitamin D inadequacy, which may have clinical relevance for skeletal morbidity, infections, and cancer outcome. This study aimed to evaluate vitamin D status at the time of diagnosis to investigate its predictors and association with overall survival in children with leukemia.

PROCEDURE:

We included all 295 children and adolescents diagnosed with leukemia at our institution between 1990 and 2016 who had available serum sample from the time of diagnosis. We analyzed serum 25-hydroxyvitamin D and parathyroid hormone levels and correlated them with clinical data.

RESULTS:

The 25-hydroxyvitamin D level was deficient (< 25 nmol/L), insufficient (25-50 nmol/L), sufficient (50-75 nmol/L), and optimal (> 75 nmol/L) in 6.4%, 26.8%, 39.7%, and 27.1% of the children, respectively. Older age and a more recent time of sampling (calendar year) predicted lower 25-hydroxyvitamin D level. In preschool children (age ≤6 years), lower 25-hydroxyvitamin D level was also associated with acute myeloid leukemia, and a 25-hydroxyvitamin D level < 50 nmol/L was associated with inferior overall survival. In school-aged children (age > 6 years), the 25-hydroxyvitamin D level showed significant seasonal variation.

CONCLUSION:

It remains unclear whether vitamin D supplementation in pediatric leukemia patients will improve outcome.

• Authors: Natalja Jackmann, Outi Mäkitie, Arja Harila-Saari, Jan Gustafsson, Dzeneta Nezirevic Dernroth, Per Frisk
• Journal: Pediatric blood & cancer (Pediatr Blood Cancer) Vol. 67 Issue 4 Pg. e28163 (04 2020) ISSN: 1545-5017 [Electronic] United States
• PMID: 31925904 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2020 Wiley Periodicals, Inc.

Chemical References

• Vitamin D
• 25-hydroxyvitamin D

Topics

• Adolescent
• Child
• Child, Preschool
• Cross-Sectional Studies
• Female
• Follow-Up Studies
• Humans
• Incidence
• Infant
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive (blood, epidemiology, mortality)
• Leukemia, Myeloid, Acute (blood, epidemiology, mortality)
• Leukemia, Myelomonocytic, Juvenile (blood, epidemiology, mortality)
• Male
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (blood, epidemiology, mortality)
• Prognosis
• Retrospective Studies
• Seasons
• Survival Rate
• Sweden (epidemiology)
• Vitamin D (analogs & derivatives, blood)
• Vitamin D Deficiency (physiopathology)