Development of autoantibody signatures for common cancers.

Abstract

A humoral immune response in the form of autoantibodies to tumor antigens occurs early during tumor development. Identification of antigens that induce an autoantibody response restricted to a cancer type has the potential to yield markers useful for early detection. A multitude of strategies are currently available for the discovery of tumor antigens directed autoantibodies in circulation. Each approach has advantages and limitations for comprehensive discovery of antigenic epitopes. Herein, we review established and novel strategies and methodologies and highlight potential cancer applications.

• Authors: Makoto Kobayashi, Hiroyuki Katayama, Johannes F Fahrmann, Samir M Hanash
• Journal: Seminars in immunology (Semin Immunol) Vol. 47 Pg. 101388 (02 2020) ISSN: 1096-3618 [Electronic] England
• PMID: 31924500 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Published by Elsevier Ltd.

Chemical References

• Antigen-Antibody Complex
• Antigens, Neoplasm
• Autoantibodies
• Autoantigens
• Biomarkers, Tumor
• Epitopes
• Peptides

Topics

• Antigen-Antibody Complex (immunology)
• Antigens, Neoplasm (immunology)
• Autoantibodies (genetics, immunology)
• Autoantigens (immunology)
• Biomarkers, Tumor
• Cell Surface Display Techniques
• Computational Biology (methods)
• Early Detection of Cancer
• Epitope Mapping (methods)
• Epitopes (immunology)
• Humans
• Neoplasms (diagnosis, genetics, immunology)
• Peptides (genetics, immunology)
• Prognosis
• Proteomics (methods)