Impact of Stereotactic Ventriculocisternostomy on Delayed Cerebral Infarction and Outcome After Subarachnoid Hemorrhage.

Abstract

Background and Purpose- Delayed cerebral infarction (DCI) is an important cause of morbidity and mortality in patients with aneurysmal subarachnoid hemorrhage (aSAH). Stereotactic catheter ventriculocisternostomy (STX-VCS) and fibrinolytic/spasmolytic lavage is a new method for DCI prevention. Here, we assess the effects of implementing STX-VCS in an unselected aSAH patient population of a tertiary referral center. Methods- Retrospective cohort study of all consecutive aSAH patients admitted to a neurosurgical referral center during a 7-year period (April 2012 to April 2019). Midterm STX-VCS was introduced and offered to patients at high risk for DCI. We compared the incidence and burden of DCI, neurological outcome, and the use of induced hypertension and endovascular rescue therapy in this consecutive aSAH population 3.5 years before versus 3.5 years after STX-VCS became available. Results- Four hundred thirty-six consecutive patients were included: 222 BEFORE and 214 AFTER. Fifty-seven of 214 (27%) patients received STX-VCS. Stereotactic procedures resulted in one (2%) subdural hematoma. Favorable neurological outcome at 6 months occurred in 118 (53%) patients BEFORE and 139 (65%) patients AFTER (relative risk, 0.79 [95% CI, 0.66-0.95]). DCI occurred in 40 (18.0%) patients BEFORE and 17 (7.9%) patients AFTER (relative risk, 0.68 [95% CI, 0.57-0.86]), and total DCI volumes were 8933 (100%) and 3329 mL (36%), respectively. Induced hypertension was used in 97 (44%) and 30 (15%) patients, respectively (relative risk, 0.55 [95% CI, 0.46-0.65]). Thirty (13.5%) patients BEFORE versus 5 (2.3%) patients AFTER underwent endovascular rescue therapies (relative risk, 0.17 [95% CI, 0.07-0.42]). Conclusions- Selecting high-risk patients for STX-VCS reduced the DCI incidence, burden, and related mortality in a consecutive aSAH patient population. This was associated with an improved neurological outcome.

• Authors: Roland Roelz, Jan Hendrik Schaefer, Christian Scheiwe, Bastian Sajonz, Istvan Csok, Christine Steiert, Jürgen Buttler, Eva Rohr, Jürgen Grauvogel, Mukesch J Shah, Karl Egger, Wolf-Dirk Niesen, Jürgen Bardutzky, Jürgen Beck, Volker A Coenen, Peter C Reinacher
• Journal: Stroke (Stroke) Vol. 51 Issue 2 Pg. 431-439 (02 2020) ISSN: 1524-4628 [Electronic] United States
• PMID: 31795898 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Fibrinolytic Agents
• Vasodilator Agents
• Nimodipine
• Urokinase-Type Plasminogen Activator

Topics

• Aged
• Aneurysm, Ruptured
• Cerebral Infarction (etiology, prevention & control)
• Female
• Fibrinolytic Agents (administration & dosage)
• Humans
• Intracranial Aneurysm
• Male
• Middle Aged
• Nimodipine (administration & dosage)
• Patient Selection
• Retrospective Studies
• Stereotaxic Techniques
• Subarachnoid Hemorrhage (complications, therapy)
• Therapeutic Irrigation (methods)
• Urokinase-Type Plasminogen Activator (administration & dosage)
• Vasodilator Agents (administration & dosage)
• Vasospasm, Intracranial (etiology, therapy)
• Ventriculostomy (methods)