Prognostic value of von Willebrand factor for patients with atrial fibrillation: a meta-analysis of prospective cohort studies.

Abstract

BACKGROUND:

It is unknown whether an abnormal level of von Willebrand factor (vWF) is correlated with the prognosis of patients with atrial fibrillation (AF) and current findings are controversial. This meta-analysis aimed to evaluate the association between vWF levels and the clinical prognosis of patients with AF.

METHODS:

We searched prospective cohort studies on PubMed, Embase, Web of Science, Cochrane Library and WanFang databases for vWF and adverse events of AF from inception of the databases to July 2019. The risk ratios of all-cause death, cardiovascular death, major adverse cardiac events (MACE), stroke and bleeding prognosis in patients with AF were analysed using a fixed-effects model or random-effects model, and all included studies were evaluated with heterogeneity and publication bias analysis.

RESULTS:

Twelve studies which included 7449 patients with AF were used in the meta-analysis. The average age was 71.3 years and the average follow-up time was 3.38 years. The analysis found that high vWF levels were associated with increased risks of all-cause death (RR 1.56; 95% CI 1.16 to 2.11, p=0.00400), cardiovascular death (RR 1.91; 95% CI 1.20 to 3.03, p=0.00600), MACE (RR 1.83; 95% CI 1.28 to 2.62, p=0.00090), stroke (RR 1.69; 95% CI 1.08 to 2.64, p=0.02000) and bleeding (RR 2.01; 95% CI 1.65 to 2.45, p<0.00001) in patients with AF.

CONCLUSIONS:

vWF is a risk factor for poor prognosis of AF, and patients with higher vWF levels have a higher risk of all-cause death, cardiovascular death, MACE, stroke and bleeding.

• Authors: Yuan-Zheng Ye, Ya-Fei Chang, Bao-Zhu Wang, Yi-Tong Ma, Xiang Ma
• Journal: Postgraduate medical journal (Postgrad Med J) Vol. 96 Issue 1135 Pg. 267-276 (May 2020) ISSN: 1469-0756 [Electronic] England
• PMID: 31771966 (Publication Type: Journal Article, Meta-Analysis)
• Copyright: © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.

Chemical References

• Biomarkers
• von Willebrand Factor

Topics

• Atrial Fibrillation (blood)
• Biomarkers (analysis)
• Cause of Death
• Humans
• Prognosis
• Prospective Studies
• Risk Factors
• von Willebrand Factor (analysis)