How It Works: The Immunology Underlying Phototherapy.

Abstract	Phototherapeutic modalities induce apoptosis of keratinocytes and immune cells, impact cytokine production, downregulate the IL-23/Th17 axis, and induce regulatory T cells. As in anti-IL-17 or anti-IL-23 antibody treatment, the dual action of phototherapy on skin and the immune system is likely responsible for sustained resolution of lesions in diseases such as psoriasis. In cutaneous T cell lymphoma, phototherapy may function by causing tumor cell apoptosis and eliminating the neoplastic and inflammatory infiltrate. Further research on phototherapeutic mechanisms will help advance, optimize, and refine dermatologic treatments and may open up novel avenues for treatment strategies in dermatology and beyond.
Authors	Zizi Yu, Peter Wolf
Journal	Dermatologic clinics (Dermatol Clin) Vol. 38 Issue 1 Pg. 37-53 (Jan 2020) ISSN: 1558-0520 [Electronic] United States
PMID	31753191 (Publication Type: Journal Article, Review)
Copyright	Copyright © 2019 Elsevier Inc. All rights reserved.
Topics	Humans Immunity, Cellular Keratinocytes (immunology, pathology) Phototherapy (methods) Psoriasis (immunology, pathology, therapy) T-Lymphocytes, Regulatory (immunology)

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