Local dermal application of a compound lidocaine cream in pain management of cancer wounds.

Abstract

The aim of this study was to explore the analgesic effect of local application of compound lidocaine/prilocaine cream on cancer wounds during wound care in order to reduce the amount of morphine intake or completely replace the systemic morphine administration and optimize the protocol for cancer wound pain management. All patients were enrolled with a visual analog scale (VAS) pain score ≥4. Before wound care, 60 patients were randomly divided into 2 groups of 30 each: morphine group (10 mg tablet); topical 5% compound lidocaine cream group (0.2 g/cm2). VAS scores, heart rate, and Kolcaba comfort level were recorded for the two groups 10 min before and 10, 15, 20, and 25 min after wound care and data were analyzed statistically. The means for the pain score and heart rate of the topical lidocaine/prilocaine cream group were lower than those of the morphine group (P<0.01) and the Kolcaba comfort level was higher (P<0.01). Local dermal application of the compound lidocaine cream can be used as an alternative to the systemic morphine administration in cancer wound care for its safety and effectiveness. In addition, it can improve the patients' comfort and quality of life.

• Authors: L Peng, H Y Zheng, Y Dai
• Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas (Braz J Med Biol Res) Vol. 52 Issue 11 Pg. e8567 ( 2019) ISSN: 1414-431X [Electronic] Brazil
• PMID: 31721905 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Anesthetics, Combined
• Lidocaine, Prilocaine Drug Combination

Topics

• Adult
• Aged
• Anesthetics, Combined (administration & dosage)
• Female
• Humans
• Lidocaine, Prilocaine Drug Combination (administration & dosage)
• Male
• Middle Aged
• Neoplasms (complications)
• Pain Management (methods)
• Pain Measurement
• Quality of Life
• Treatment Outcome
• Wounds and Injuries (drug therapy, etiology)