Abstract | PURPOSE: Impaired health-related quality of life (HRQoL) is associated with poor health outcomes in chronic obstructive pulmonary disease ( COPD). The aim of this study was to determine health utilities in patients with COPD and to identify the variables with the greatest impact. METHODS: This is a pooled analysis of data from 4 observational studies performed in stable COPD patients. Evaluation of patient HRQoL utilities was performed using the Spanish version of the self-administered EuroQoL 5 Dimensions (EQ-5D) questionnaire. EQ-5D utilities were described and compared according to several markers of disease severity. RESULTS: 6198 patients reported a mean (SD) EQ-5D index of 0.67 (0.26). A linear dose response relationship between EQ-5D utility and modified Medical Research Council (mMRC) score, forced expiratory volume in one 1 s (% predicted), COPD hospital admissions in the previous year, self-reported daily walking time, Charlson index, body mass index, obstruction, dyspnoea and exacerbation (BODEx) index, COPD assessment test (CAT), hospital anxiety and depression scale was observed (p for trend < 0.001). In multivariate analysis, patients reporting lower utility values were those with more dyspnoea, more comorbidities, using long-term oxygen therapy, with previous hospitalisations due to a COPD exacerbation and higher (worse) CAT score. CONCLUSION: HRQoL measures such as EQ-5D can assist clinicians to understand the impact of respiratory disease on COPD patients.
|
Authors | Cristina Esquinas, Maria A Ramon, Alexa Nuñez, Jesús Molina, José A Quintano, Miguel Roman-Rodríguez, Karlos Naberan, Carl Llor, Carlos Roncero, Marc Miravitlles, Miriam Barrecheguren |
Journal | Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
(Qual Life Res)
Vol. 29
Issue 3
Pg. 607-617
(Mar 2020)
ISSN: 1573-2649 [Electronic] Netherlands |
PMID | 31673922
(Publication Type: Journal Article, Multicenter Study)
|
Topics |
- Aged
- Cross-Sectional Studies
- Female
- Humans
- Male
- Pulmonary Disease, Chronic Obstructive
(physiopathology)
- Quality of Life
(psychology)
|