[The clinical usefulness of the measurement of serum sialyl SSEA-1 antigen levels in patients with gynecologic diseases: as respects the comparative effectiveness of sialyl SSEA-1 and CA125].

Abstract

Increased concentrations of serum Sialyl SSEA-1 antigen, which belongs to type 2 chain carbohydrate antigens and is defined by a new monoclonal antibody FH-6, were observed in 47.2% of patients with ovarian cancer. The Sialyl SSEA-1 test may not be of use in detecting ovarian cancer in the early stages, because the positivity gradually increased with the clinical stages. However, the measurement of the Sialyl SSEA-1 concentrations was a useful tool to use in making a prognosis. The sialyl SSEA-1 and CA125 combination test was not useful in increasing sensitivity because of overlapping of the positivity. Increases in both serum Sialyl SSEA-1 and CA125 indicated the presence of malignancies associated with ovarian tumors in pregnant women. On the other hand, the Sialyl SSEA-1 test showed significantly low false positivity for non-neoplastic diseases except endometriosis.

• Authors: H Kobayashi
• Journal: Nihon Sanka Fujinka Gakkai zasshi (Nihon Sanka Fujinka Gakkai Zasshi) Vol. 40 Issue 7 Pg. 828-34 (Jul 1988) ISSN: 0300-9165 [Print] Japan
• PMID: 3166483 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antigens, Neoplasm
• Antigens, Tumor-Associated, Carbohydrate
• Biomarkers, Tumor

Topics

• Antigens, Neoplasm (analysis)
• Antigens, Tumor-Associated, Carbohydrate
• Biomarkers, Tumor (blood)
• Endometriosis (diagnosis)
• Female
• Humans
• Ovarian Neoplasms (diagnosis)
• Pregnancy
• Pregnancy Complications, Neoplastic (diagnosis)