The Role of Adaptor Protein CARD9 in Colitis-Associated Cancer.

Abstract

The adaptor protein CARD9 plays an important role in anti-fungal immunity responses, linking detection of fungi by surface receptors to activation of the transcription factor nuclear factor κB (NF-κB). Recent studies indicate that CARD9 also plays different but vital roles during the development of colitis-associated colorectal cancer (CAC). This review summarizes the current understanding of CARD9 functions in CAC, and we discuss its potentially carcinogenic mechanisms.

• Authors: Xiaoming Zhong, Bin Chen, Min Liu, Zhiwen Yang
• Journal: Molecular therapy oncolytics (Mol Ther Oncolytics) Vol. 15 Pg. 1-6 (Dec 20 2019) ISSN: 2372-7705 [Print] United States
• PMID: 31650020 (Publication Type: Journal Article, Review)
• Copyright: © 2019 The Authors.