DAV131A Protects Hamsters from Lethal Clostridioides difficile Infection Induced by Fluoroquinolones.

Abstract

Fluoroquinolone treatments induce dysbiosis of the intestinal microbiota, resulting in loss of resistance to colonization by exogenous bacteria such as Clostridioides difficile that may cause severe diarrhea in humans and lethal infection in hamsters. We show here that DAV131A, a charcoal-based adsorbent, decreases the intestinal levels of the fluoroquinolone antibiotics levofloxacin and ciprofloxacin in hamsters, protects their intestinal microbiota, and prevents lethal infection by C. difficile.

• Authors: Nathalie Saint-Lu, Charles Burdet, Frédérique Sablier-Gallis, Tanguy Corbel, Agathe Nevière, Sakina Sayah-Jeanne, Mark Pulse, William Weiss, Stéphanie Ferreira, Antoine Andremont, France Mentré, Jean de Gunzburg
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 64 Issue 1 (12 20 2019) ISSN: 1098-6596 [Electronic] United States
• PMID: 31636067 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2019 American Society for Microbiology.

Chemical References

• Anti-Bacterial Agents
• Fluoroquinolones
• Charcoal
• Ciprofloxacin
• Levofloxacin

Topics

• Administration, Oral
• Adsorption
• Animals
• Anti-Bacterial Agents (adverse effects, pharmacokinetics)
• Charcoal (administration & dosage)
• Ciprofloxacin (adverse effects, pharmacokinetics)
• Clostridioides difficile (pathogenicity)
• Clostridium Infections (prevention & control)
• Disease Models, Animal
• Dysbiosis (chemically induced, metabolism, prevention & control)
• Fluoroquinolones (adverse effects, pharmacokinetics)
• Gastrointestinal Microbiome (drug effects)
• Levofloxacin (adverse effects, pharmacokinetics)
• Male
• Mesocricetus