Development of Expert-Level Automated Detection of Epileptiform Discharges During Electroencephalogram Interpretation.

Abstract

Importance:

Interictal epileptiform discharges (IEDs) in electroencephalograms (EEGs) are a biomarker of epilepsy, seizure risk, and clinical decline. However, there is a scarcity of experts qualified to interpret EEG results. Prior attempts to automate IED detection have been limited by small samples and have not demonstrated expert-level performance. There is a need for a validated automated method to detect IEDs with expert-level reliability.

Objective:

To develop and validate a computer algorithm with the ability to identify IEDs as reliably as experts and classify an EEG recording as containing IEDs vs no IEDs.

Design, Setting, and Participants:

A total of 9571 scalp EEG records with and without IEDs were used to train a deep neural network (SpikeNet) to perform IED detection. Independent training and testing data sets were generated from 13 262 IED candidates, independently annotated by 8 fellowship-trained clinical neurophysiologists, and 8520 EEG records containing no IEDs based on clinical EEG reports. Using the estimated spike probability, a classifier designating the whole EEG recording as positive or negative was also built.

Main Outcomes and Measures:

SpikeNet accuracy, sensitivity, and specificity compared with fellowship-trained neurophysiology experts for identifying IEDs and classifying EEGs as positive or negative or negative for IEDs. Statistical performance was assessed via calibration error and area under the receiver operating characteristic curve (AUC). All performance statistics were estimated using 10-fold cross-validation.

Results:

SpikeNet surpassed both expert interpretation and an industry standard commercial IED detector, based on calibration error (SpikeNet, 0.041; 95% CI, 0.033-0.049; vs industry standard, 0.066; 95% CI, 0.060-0.078; vs experts, mean, 0.183; range, 0.081-0.364) and binary classification performance based on AUC (SpikeNet, 0.980; 95% CI, 0.977-0.984; vs industry standard, 0.882; 95% CI, 0.872-0.893). Whole EEG classification had a mean calibration error of 0.126 (range, 0.109-0.1444) vs experts (mean, 0.197; range, 0.099-0.372) and AUC of 0.847 (95% CI, 0.830-0.865).

Conclusions and Relevance:

In this study, SpikeNet automatically detected IEDs and classified whole EEGs as IED-positive or IED-negative. This may be the first time an algorithm has been shown to exceed expert performance for IED detection in a representative sample of EEGs and may thus be a valuable tool for expedited review of EEGs.

• Authors: Jin Jing, Haoqi Sun, Jennifer A Kim, Aline Herlopian, Ioannis Karakis, Marcus Ng, Jonathan J Halford, Douglas Maus, Fonda Chan, Marjan Dolatshahi, Carlos Muniz, Catherine Chu, Valeria Sacca, Jay Pathmanathan, Wendong Ge, Justin Dauwels, Alice Lam, Andrew J Cole, Sydney S Cash, M Brandon Westover
• Journal: JAMA neurology (JAMA Neurol) Vol. 77 Issue 1 Pg. 103-108 (01 01 2020) ISSN: 2168-6157 [Electronic] United States
• PMID: 31633740 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Topics

• Electroencephalography
• Epilepsy (diagnosis)
• Humans
• Neural Networks, Computer
• Sensitivity and Specificity
• Signal Processing, Computer-Assisted
• Software