Tamsulosin Monotherapy Is Effective in Reducing Ureteral Stent-related Symptoms: A Meta-analysis of Randomized Controlled Studies.

Abstract

This study aimed to evaluate the effectiveness of tamsulosin monotherapy for the treatment of ureteral stent-related symptoms (SRSs) and compare it with that of solifenacin monotherapy and combined therapy of tamsulosin and silifenacin. Randomized controlled trials (RCTs), which evaluated the effectiveness of tamsulosin for the treatment of SRSs, were searched from the databases PubMed, EMBASE and the Cochrane Library published up to November 2018. Eight RCTs involving 1087 participants were finally included in this meta-analysis. The results showed that tamsulosin monotherapy could significantly decrease the urinary symptoms [mean difference (MD) -7.56, 95% confidence interval (CI) (-11.47, -3.65), P=0.0001] and body pain [MD -5.25, 95% CI (-8.03, -2.46), P=0.0002], and improve the sexual performance [MD -1.06, 95% CI (-1.89, -0.24), P=0.01] compared with the control group. Moreover, there was no significant difference between tamsulosin monotherapy and solifenacin monotherapy in all outcomes except for significantly better sexual performance in solifenacin group [MD 0.29, 95% CI (0.06, 0.51), P=0.01]. In addition, the effectiveness of combined therapy of tamsulosin and solifenacin was not superior to that of tamsulosin monotherapy. Our study demonstrated that tamsulosin monotherapy was effective for the treatment of patients with SRSs; evident superiority could not be found for therapy of tamsulosin and solifenacin combined.

• Authors: Yong-Bo Chen, Liang Gao, Qing Jiang, Ke Ran, Run-Tian Luo
• Journal: Current medical science (Curr Med Sci) Vol. 39 Issue 5 Pg. 707-718 (Oct 2019) ISSN: 2523-899X [Electronic] China
• PMID: 31612387 (Publication Type: Journal Article, Meta-Analysis)

Chemical References

• Adrenergic alpha-1 Receptor Antagonists
• Urological Agents
• Tamsulosin
• Solifenacin Succinate

Topics

• Adrenergic alpha-1 Receptor Antagonists (therapeutic use)
• Drug Therapy, Combination
• Female
• Humans
• Lower Urinary Tract Symptoms (drug therapy, etiology, physiopathology)
• Male
• Randomized Controlled Trials as Topic
• Solifenacin Succinate (therapeutic use)
• Stents (adverse effects)
• Tamsulosin (therapeutic use)
• Treatment Outcome
• Ureteral Diseases (surgery)
• Urological Agents (therapeutic use)