Abstract | OBJECTIVE: METHODS: RESULTS: Twenty-five patients were enrolled in the aSAH group and 9 were enrolled in the NPH group. There was a significant increase in aggregate CSF MIF concentration in patients with aSAH versus those with NPH (24.4 ± 19.2 vs 2.3 ± 1.1 ng/ml, p < 0.0002). Incidence of the day of peak MIF concentration significantly correlated with the onset of clinical vasospasm (rho = 0.778, p < 0.0010). MIF concentrations were significantly elevated in patients with versus those without evidence of DCI (18.7 ± 4.93 vs 8.86 ± 1.28 ng/ml, respectively, p < 0.0025). There was a significant difference in MIF concentrations between patients with infection versus those without infection (16.43 ± 4.21 vs 8.5 ± 1.22 ng/ml, respectively, p < 0.0119). CONCLUSIONS: Preliminary evidence from this study suggests that CSF concentrations of MIF are correlated with CV and DCI. These results, however, could be confounded in the presence of clinical infection. A study with a larger patient sample size is necessary to corroborate these findings.
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Authors | Kevin Kwan, Orseola Arapi, Katherine E Wagner, Julia Schneider, Heustein L Sy, Mary Frances Ward, Cristina P Sison, Chunyan Li, Mark B Eisenberg, David Chalif, Raj K Narayan, Edmund J Miller, David Ledoux |
Journal | Journal of neurosurgery
(J Neurosurg)
Vol. 133
Issue 6
Pg. 1786-1791
(Oct 04 2019)
ISSN: 1933-0693 [Electronic] United States |
PMID | 31585427
(Publication Type: Journal Article)
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