Matrix metalloproteinase-2-targeted superparamagnetic Fe3O4-PEG-G5-MMP2@Ce6 nanoprobes for dual-mode imaging and photodynamic therapy.

Abstract	This work explored the application of matrix metalloproteinase 2-targeted superparamagnetic nanoprobes for magnetic resonance imaging (MRI), near infrared (NIR) fluorescence imaging and photodynamic therapy of tumors. PEG, PAMAM (G5) and matrix metalloproteinase 2 (MMP2) were attached to the surface of carboxylated Fe3O4 nanoparticles (NPs) using a chemical coupling method and then finally loaded with the photosensitizer chlorin e6 (Ce6). In vitro and in vivo experiments demonstrated that the Fe3O4-PEG-G5-MMP2@Ce6 nanoprobes exhibited excellent stability, precise tumor targeting and biocompatibility. Furthermore, the fluorescence properties of Fe3O4-PEG-G5-MMP2@Ce6 nanoprobes were analogous to Ce6 and could be employed for fluorescence imaging. Meanwhile, the Fe3O4-PEG-G5-MMP2@Ce6 nanoprobes have also been shown to be effective as contrast agents for T2-weighted MRI. The target molecule MMP2 enhanced the tumor targeting ability of Fe3O4-PEG-G5-MMP2@Ce6 nanoprobes. Additionally, the Fe3O4-PEG-G5-MMP2@Ce6 nanoprobes significantly inhibited tumor growth compared with PBS and free Ce6. This work will inspire greater enthusiasm for the construction of multifunctional magnetic nanoplatforms for biomedical applications.
Authors	Meng Duan , Fangfang Xia , Tianliang Li , Joseph G Shapter , Sheng Yang , Yongying Li , Guo Gao , Daxiang Cui
Journal	Nanoscale (Nanoscale) Vol. 11 Issue 39 Pg. 18426-18435 (Oct 10 2019) ISSN: 2040-3372 [Electronic] England
PMID	31576881 (Publication Type: Journal Article)
Chemical References	Chlorophyllides Magnetite Nanoparticles Photosensitizing Agents Porphyrins phytochlorin MMP2 protein, human Matrix Metalloproteinase 2
Topics	Animals Cell Line, Tumor Chlorophyllides Female Humans Magnetite Nanoparticles (chemistry, therapeutic use) Matrix Metalloproteinase 2 (chemistry, therapeutic use) Mice Mice, Inbred BALB C Mice, Nude Neoplasms, Experimental (diagnostic imaging, drug therapy) Optical Imaging Photochemotherapy Photosensitizing Agents (chemistry, pharmacology) Porphyrins (chemistry, therapeutic use) Xenograft Model Antitumor Assays

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