LncRNA NR2F2-AS1 positively regulates CDK4 to promote cancer cell proliferation in prostate carcinoma.

Abstract

We in this study investigated the role of lncRNA NR2F2-AS1 in prostate carcinoma (PC). We showed that NR2F2-AS1 was upregulated in PC and positively correlated with CDK4. In PC cells, NR2F2-AS1 overexpression led to upregulated, while NR2F2-AS1 siRNA silencing led to downregulated CDK4. Follow-up study revealed that high levels of NR2F2-AS1 and CDK4 in PC tissues were closely correlated with the poor survival of PC patients. Cell proliferation data showed that NR2F2-AS1 overexpression led to increased, while NR2F2-AS1 siRNA silencing led to proliferation rate of PC cells. Moreover, NR2F2-AS1 also showed positive effects on cell cycle progression. In addition, CDK4 overexpression reduced the effects of NR2F2-AS1 siRNA silencing. Therefore, NR2F2-AS1 positively regulates CDK4 to promote cancer cell proliferation in PC.

• Authors: Xiaoliang Fu, Dong Wang, Tao Shu, Dong Cui, Qiang Fu
• Journal: The aging male : the official journal of the International Society for the Study of the Aging Male (Aging Male) Vol. 23 Issue 5 Pg. 1073-1079 (Dec 2020) ISSN: 1473-0790 [Electronic] England
• PMID: 31566058 (Publication Type: Journal Article)

Chemical References

• COUP Transcription Factor II
• NR2F2 protein, human
• RNA, Long Noncoding
• CDK4 protein, human
• Cyclin-Dependent Kinase 4

Topics

• COUP Transcription Factor II (genetics)
• Carcinoma
• Cell Line, Tumor
• Cell Proliferation
• Cyclin-Dependent Kinase 4 (genetics)
• Follow-Up Studies
• Gene Expression Regulation, Neoplastic
• Humans
• Male
• Prostate
• RNA, Long Noncoding (genetics)