Abstract |
Unicystic ameloblastoma (UA), a benign odontogenic tumor of the jaw, represents less than a third of all ameloblastomas and seems less aggressive than other types of ameloblastoma. We present here the first case of UA that developed prenatally and was successfully managed in the early neonatal period with marsupialization and curettage performed carefully to avoid injury to the tooth germ. BRAF and SMO mutations were not detected. After 2 years of follow-up, complete reossification and normal eruption of deciduous teeth were noted, and there was no recurrence of UA. We recommend conservative treatment of UA in the pediatric population to avoid loss of and/or injury to the tooth germ, provided close follow-up is carried out all through the individual's growth for early detection of potential recurrences, growth impairments, or tooth eruption disorders. The intratumoral somatic mutational status of BRAF, SMO, RAS family, and FGFR2 may help determine personalized targeted treatment, particularly in case of recurrence.
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Authors | Anne Morice, Cecilia Neiva, Monique Fabre, Paolo Spina, Fanélie Jouenne, Eva Galliani, Marie-Paule Vazquez, Arnaud Picard |
Journal | Oral surgery, oral medicine, oral pathology and oral radiology
(Oral Surg Oral Med Oral Pathol Oral Radiol)
Vol. 129
Issue 5
Pg. e234-e242
(May 2020)
ISSN: 2212-4411 [Electronic] United States |
PMID | 31562035
(Publication Type: Case Reports, Journal Article, Review)
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Copyright | Copyright © 2019 Elsevier Inc. All rights reserved. |
Topics |
- Ameloblastoma
- Child
- Conservative Treatment
- Humans
- Infant, Newborn
- Mutation
- Neoplasm Recurrence, Local
- Odontogenic Tumors
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