Abstract | INTRODUCTION:
Infertility is common for individuals with differences of sex development (DSD) and is a significant concern to these individuals. Fertility potential in many DSD conditions is poorly understood. Gonadal tissue cryopreservation (GTC) for fertility preservation (FP) is offered to children with cancer undergoing gonadotoxic therapy. Our team sought to expand the field of FP by offering and evaluating the success of GTC for individuals with DSD. MATERIALS AND METHODS: GTC was offered to patients with DSD undergoing prophylactic gonadectomy, after extensive multidisciplinary counseling. For those who elected to attempt GTC, data were retrospectively abstracted, including: DSD diagnosis, age at gonadectomy, indication for gonadectomy, pathology results, and final decision about long-term gonadal tissue storage. RESULTS: CONCLUSION: GTC at the time of gonadectomy for patients with DSD is feasible. In many patients, GCs are present. While questions remain about the timing of gonadectomy, quality of GCs, and future success for use of the tissue based on technological advancement, GTC represents a novel approach to experimental FP for individuals with DSD.
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Authors | Emilie K Johnson, Courtney Finlayson, Esther L Finney, Courtney J Harris, Serena Y Tan, Monica M Laronda, Barbara A Lockart, Diane Chen, Erin E Rowell, Earl Y Cheng, Elizabeth B Yerkes |
Journal | Hormone research in paediatrics
(Horm Res Paediatr)
Vol. 92
Issue 2
Pg. 84-91
( 2019)
ISSN: 1663-2826 [Electronic] Switzerland |
PMID | 31509845
(Publication Type: Clinical Trial, Journal Article)
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Copyright | © 2019 S. Karger AG, Basel. |
Topics |
- Adolescent
- Child
- Child, Preschool
- Cryopreservation
- Disorders of Sex Development
(therapy)
- Female
- Fertility Preservation
- Humans
- Infant
- Male
- Retrospective Studies
- Sexual Development
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