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Gonadal Dysgenesis (Gonadal Agenesis)

A number of syndromes with defective gonadal developments such as streak GONADS and dysgenetic testes or ovaries. The spectrum of gonadal and sexual abnormalities is reflected in their varied sex chromosome (SEX CHROMOSOMES) constitution as shown by the karyotypes of 45,X monosomy (TURNER SYNDROME); 46,XX (GONADAL DYSGENESIS, 46XX); 46,XY (GONADAL DYSGENESIS, 46,XY); and sex chromosome MOSAICISM; (GONADAL DYSGENESIS, MIXED). Their phenotypes range from female, through ambiguous, to male. This concept includes gonadal agenesis.
Also Known As:
Gonadal Agenesis; Dysgenesis, Gonadal
Networked: 519 relevant articles (2 outcomes, 40 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Androgen-Insensitivity Syndrome (Testicular Feminization)
2. Ovotesticular Disorders of Sex Development
3. Disorders of Sex Development (Intersexuality)
4. Turner Syndrome (Turner's Syndrome)
5. Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal)

Experts

1. Parker, Keith L: 6 articles (08/2007 - 02/2002)
2. Rey, Rodolfo A: 5 articles (01/2020 - 01/2014)
3. Harley, Vincent R: 5 articles (12/2018 - 01/2002)
4. Domenice, Sorahia: 4 articles (01/2022 - 04/2004)
5. Köhler, Birgit: 4 articles (04/2018 - 06/2004)
6. Drop, Stenvert L S: 4 articles (01/2016 - 06/2006)
7. Looijenga, Leendert H J: 4 articles (01/2016 - 06/2006)
8. Wolffenbuttel, Katja P: 4 articles (01/2016 - 06/2006)
9. Kula, Krzysztof: 4 articles (01/2015 - 01/2003)
10. Gravholt, Claus Højbjerg: 4 articles (02/2005 - 01/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Gonadal Dysgenesis:
1. Transcription Activator-Like Effector NucleasesIBA
2. AndrogensIBA
3. Estrogens (Estrogen)FDA Link
4. Prostaglandins DIBA
5. DNA (Deoxyribonucleic Acid)IBA
6. Androgen Receptors (Androgen Receptor)IBA
7. GonadotropinsIBA
8. Testosterone (Sustanon)FDA Link
9. H-Y AntigenIBA
10. Progestins (Progestagens)IBA

Therapies and Procedures

1. Laparotomy
2. Therapeutics
3. Estrogen Replacement Therapy
4. Castration
5. Hormone Replacement Therapy (Therapy, Hormone Replacement)