Abstract | PURPOSE: PATIENTS AND METHODS: Thirty symptomatic women with laparoscopic diagnosis of endometriosis and pregnancy desire were enrolled. Patients were treated with um-PEA twice daily for 10 days followed by m(PEA/ PLD) twice daily for 80 days. Intensity of chronic pelvic pain, dyspareunia, dysmenorrhea, dyschezia, and dysuria were evaluated at baseline, after 10, 30, 60, 90 days and after 30 days from the end of treatment, by VAS. Quality of life and women's psychological well-being were evaluated at baseline and at the end of the treatment after 90 days with 36-Item Short Form Health Survey questionnaire and Symptom Check list-90 questionnaire, respectively. All collected data were analyzed with the non-parametric Wilcoxon test. RESULTS: CONCLUSION: In spite of the study's limited sample size and the open-label design, this research suggests the efficacy of um-PEA and m(PEA/ PLD) in reducing painful symptomatology and improving quality of life as well as psychological well-being in patients suffering from endometriosis. Additionally, this treatment did not show any serious side effect, proving particularly suitable for women with pregnancy desire and without other infertility factors.
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Authors | Emanuela Stochino Loi, Alessandro Pontis, Vito Cofelice, Silvia Pirarba, Maria Francesca Fais, Angelos Daniilidis, Irene Melis, Anna Maria Paoletti, Stefano Angioni |
Journal | International journal of women's health
(Int J Womens Health)
Vol. 11
Pg. 443-449
( 2019)
ISSN: 1179-1411 [Print] New Zealand |
PMID | 31496832
(Publication Type: Journal Article)
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