Comparative in vitro pharmacodynamic analysis of isavuconazole, voriconazole, and posaconazole against clinical isolates of aspergillosis, mucormycosis, fusariosis, and phaeohyphomycosis.

Abstract	We compared the in vitro pharmacodynamics of isavuconazole, voriconazole, and posaconazole against 92 clinical isolates from documented cases of invasive aspergillosis, mucormycosis, fusariosis, and phaeohyphomycosis. Whereas inhibitory and fungicidal concentrations of these triazoles were predictably similar with the exception of Mucorales, isavuconazole appeared to have improved pharmacodynamics against Fusarium solani.
Authors	Russell E Lewis, Sebastian Wurster, Nicholas D Beyda, Nathaniel D Albert, Dimitrios P Kontoyiannis
Journal	Diagnostic microbiology and infectious disease (Diagn Microbiol Infect Dis) Vol. 95 Issue 3 Pg. 114861 (Nov 2019) ISSN: 1879-0070 [Electronic] United States
PMID	31427139 (Publication Type: Comparative Study, Journal Article)
Copyright	Copyright © 2019 Elsevier Inc. All rights reserved.
Chemical References	Antifungal Agents Triazoles
Topics	Antifungal Agents (pharmacology) Fungi (drug effects, isolation & purification) Humans Microbial Sensitivity Tests Mycoses (microbiology) Species Specificity Triazoles (pharmacology)

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