Rate of three-dimensional neuroretinal rim thinning in glaucomatous eyes with optic disc haemorrhage.

Abstract

BACKGROUND:

To investigate the thinning rate of three-dimensional neuroretinal rim thickness (3D-NRT) in glaucoma eyes with optic disc haemorrhage (DH) and its relationship to retinal nerve fibre layer thickness (RNFLT) progression.

METHODS:

Ninety-five (95) eyes of 95 glaucoma patients with initial DH in the inferotemporal (n=69) and superotemporal (n=26) regions and 48 eyes of 48 glaucoma patients without DH were retrospectively reviewed. The rates of change for 3D-NRT and RNFLT were compared by linear mixed-effect model. For the direct comparison between 3D-NRT and RNFLT, dynamic-range-based normalised coefficient was used. The effect of DH frequency on the rates of thinning of 3D-NRT and RNFLT was evaluated.

RESULTS:

During a mean 7-year follow-up, the rates of thinning of 3D-NRT (-5.69±4.88 µm/year) and RNFLT (-2.03±2.03 µm/year) at 7 o'clock were faster than those at other locations (all p<0.05) in DH eyes. The dynamic-range-based normalised rate of thinning was significantly faster for RNFLT (-2.06%±1.62%/year) than for 3D-NRT (-1.15%±1.10%/year, p<0.001) in DH eyes, but not in non-DH eyes (p=0.43). DH frequency in the inferotemporal region was associated with the thinning rate of 3D-NRT as well as RNFLT.

CONCLUSION:

DH eyes are associated with the progression of both 3D-NRT and RNFLT, especially in the inferotemporal region. DH eyes show a relatively faster thinning rate of average RNFLT than 3D-NRT. The frequency of DH can affect the progression of 3D-NRT as well as RNFLT.

• Authors: Yong Woo Kim, Won June Lee, Bo Ram Seol, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
• Journal: The British journal of ophthalmology (Br J Ophthalmol) Vol. 104 Issue 5 Pg. 648-654 (05 2020) ISSN: 1468-2079 [Electronic] England
• PMID: 31395698 (Publication Type: Comparative Study, Journal Article, Observational Study)
• Copyright: © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.

Topics

• Female
• Follow-Up Studies
• Glaucoma, Open-Angle (complications, diagnosis, physiopathology)
• Humans
• Imaging, Three-Dimensional (methods)
• Intraocular Pressure (physiology)
• Male
• Middle Aged
• Nerve Fibers (pathology)
• Optic Disk (blood supply, pathology)
• Retinal Ganglion Cells (pathology)
• Retinal Hemorrhage (diagnosis, etiology)
• Retrospective Studies
• Tomography, Optical Coherence (methods)