Prediagnostic Level of Dietary and Urinary Isoflavonoids in Relation to Risk of Liver Cancer in Shanghai, China.

Abstract

BACKGROUND:

No epidemiologic studies have directly assessed the association between dietary and urinary isoflavonoids and risk of liver cancer in humans.

METHODS:

A nested case-control study, including 217 incident cases of liver cancer and 427 individually matched control subjects, was conducted in Shanghai, China. Dietary isoflavonoid intakes were assessed through a validated food-frequency questionnaire and the Chinese Food Composition Tables. Urinary excretion levels of four major isoflavonoids were measured by the reversed-phase high-performance liquid chromatography. ORs and 95% confidence intervals (CI) were derived using conditional logistic regression models.

RESULTS:

The adjusted ORs (95% CIs) for liver cancer across increasing quartiles of urinary genistein levels were 1.00 (reference), 0.55 (95% CI, 0.22-1.36), 0.57 (95% CI, 0.23-1.43), and 0.19 (95% CI, 0.06-0.59) (P trend = 0.008) in women and 1.00 (reference), 1.22 (0.52-2.86), 1.17(0.47-2.90), and 1.23 (0.55-2.76) in men, respectively. These associations were consistent by limiting the cases to primary malignant neoplasm of liver or malignant neoplasms of the intrahepatic bile ducts, or among participants without self-reported liver disease or cirrhosis at the baseline survey. No associations were found between dietary isoflavonoids and liver cancer risk.

CONCLUSIONS:

Our study suggests for the first time that urinary excretion of genistein may be associated with reduced risk of liver cancer in women.

IMPACT:

In this nested case-control study in China, we found that urinary excretion of genistein was associated with lower risk of liver cancer in women, and not in men.

• Authors: Wei Zhang, Jing Wang, Jing Gao, Hong-Lan Li, Li-Hua Han, Qing Lan, Nathaniel Rothman, Wei Zheng, Xiao-Ou Shu, Yong-Bing Xiang
• Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (Cancer Epidemiol Biomarkers Prev) Vol. 28 Issue 10 Pg. 1712-1719 (10 2019) ISSN: 1538-7755 [Electronic] United States
• PMID: 31387968 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: ©2019 American Association for Cancer Research.

Chemical References

• Biomarkers, Tumor
• Isoflavones

Topics

• Biomarkers, Tumor (urine)
• Case-Control Studies
• China (epidemiology)
• Diet (statistics & numerical data)
• Female
• Humans
• Incidence
• Isoflavones (metabolism, urine)
• Liver Neoplasms (diagnosis, epidemiology, urine)
• Male
• Middle Aged
• Predictive Value of Tests
• Risk Factors