Abstract | BACKGROUND AND AIM: METHODS: Overall, we enrolled 152 adults with cirrhosis in this study. Cramp questionnaires were obtained after informed consent. Study variables (demographics, physical findings, serum metabolic panel, and drugs taken that affect muscle cramps) were extracted from medical records. Body composition, including muscle volume, was analyzed using a bioelectrical impedance analysis method, and muscle strength (handgrip) was evaluated at enrollment. Cross-sectional skeletal muscle area was evaluated on computed tomography imaging at the L3 vertebral level to investigate the relationship between muscle cramps and sarcopenia. RESULTS: The proportion of furosemide administration was higher in patients with cramping compared with those without. On a multivariate logistic regression analysis, furosemide use was a significant factor in the presence of muscle cramps. Furthermore, regarding factors contributing to muscle cramp severity, furosemide use was extracted by multivariate logistic regression analysis. In the presence or severity of muscle cramps, skeletal muscles did not show any significant difference. CONCLUSIONS:
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Authors | Yasuhiko Sawada, Hideto Kawaratani, Takuya Kubo, Yukihisa Fujinaga, Masanori Furukawa, Soichiro Saikawa, Shinya Sato, Hiroaki Takaya, Kosuke Kaji, Naotaka Shimozato, Kei Moriya, Tadashi Namisaki, Takemi Akahane, Akira Mitoro, Hitoshi Yoshiji |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 35
Issue 1
Pg. 76-81
(Jan 2020)
ISSN: 1440-1746 [Electronic] Australia |
PMID | 31385352
(Publication Type: Journal Article)
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Copyright | © 2019 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. |
Chemical References |
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Topics |
- Aged
- Diuretics
(adverse effects)
- Female
- Furosemide
(adverse effects)
- Humans
- Liver Cirrhosis
(complications)
- Male
- Middle Aged
- Muscle Cramp
(etiology)
- Risk Factors
- Sarcopenia
(chemically induced)
- Surveys and Questionnaires
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