Abstract |
This chapter reviews pharmacotherapies that have been trialled for cannabis dependence, identifying those that warrant further research and those of little or uncertain value. A diverse range of medicines have been tested, representing a broad range of pharmacological strategies. These include tetrahydrocannabinol preparations, various types of antidepressant, anxiolytics, a glutamatergic modulator and the neuropeptide oxytocin. Cannabinoid agonists warrant further research. For the FAAH inhibitor PF-04457845, oxytocin, varenicline and gabapentin, although there is a signal to indicate further research is warranted, these medications do not yet have sufficient evidence to support clinical use, and larger, longer-term trials are needed in representative treatment-seeking populations. Special populations that warrant consideration are those with cannabis dependence and concurrent mental health conditions and those that develop dependence through therapeutic use.
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Authors | Suzanne Nielsen, Pamela Sabioni, Linda Gowing, Bernard Le Foll |
Journal | Handbook of experimental pharmacology
(Handb Exp Pharmacol)
Vol. 258
Pg. 355-372
( 2020)
ISSN: 0171-2004 [Print] Germany |
PMID | 31375922
(Publication Type: Journal Article, Review)
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Chemical References |
- Cannabinoid Receptor Agonists
- Dronabinol
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Topics |
- Cannabinoid Receptor Agonists
(pharmacology)
- Cannabis
- Dronabinol
- Humans
- Marijuana Abuse
(drug therapy)
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