TFAP2A Induced KRT16 as an Oncogene in Lung Adenocarcinoma via EMT.

Abstract	Objectives: keratin 16 (KRT16) is a type I cytokeratin that overexpressed in many kinds of cancers, but unlike other keratins, KRT16 was poorly studied, so the aim of current study was to determine the biological role of KRT16 in lung adenocarcinoma (LUAD). Materials and Methods: by utilizing open access data, we determined KRT16 expression in LUAD. After that we evaluated the biological role of KRT16 in-vitro and in-vivo. We also explored the reason for KRT16 overexpression. Last, we explored the clinical significance of KRT16 in LUAD. Results: we found KRT16 is overexpressed in LUAD and positively correlated with lymph node metastasis. Knockdown of KRT16 significantly influenced the LUAD cells' migration, invasion, proliferation and epithelial-mesenchymal transition (EMT). Moreover, TFAP2A could transcriptionally overexpress KRT16, which contributed to the TFAP2A tumorigenicity. Last, we determined that high level of KRT16 predicts poor prognosis of LUAD patients. Conclusions: our data indicate that, TFAP2A induced KRT16 overexpression promotes tumorigenicity in LUAD via EMT, and KRT16 expression could serve as an independent prognosis marker.
Authors	Liu Yuanhua, Qian Pudong, Zhu Wei, Wu Yuan, Liu Delin, Zhang Yan, Liang Geyu, Shen Bo
Journal	International journal of biological sciences (Int J Biol Sci) Vol. 15 Issue 7 Pg. 1419-1428 ( 2019) ISSN: 1449-2288 [Electronic] Australia
PMID	31337972 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	KRT16 protein, human Keratin-16 TFAP2A protein, human Transcription Factor AP-2
Topics	Adenocarcinoma (genetics, metabolism) Animals Cell Line, Tumor Cell Movement Cell Proliferation Epithelial-Mesenchymal Transition Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Keratin-16 (metabolism) Lung Neoplasms (genetics, metabolism) Lymphatic Metastasis Male Mice Mice, Nude Middle Aged Neoplasm Invasiveness Oncogenes Prognosis Tissue Array Analysis Transcription Factor AP-2 (metabolism) Wound Healing

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