Abstract | BACKGROUND: METHODS: Animals received hindlimb compressions for 6 h to induce CI. Then, animals were untreated or treated with PPD and/or massive fluid resuscitation (MFR) for 8 h since the onset of compression release. Blood and renal tissue samples were collected at various time points for biological and morphological analysis. RESULTS:
PPD attenuated lactic acidosis and reduced serum K+ and myoglobin levels in CI animals. In addition, PPD was effective in removing blood urea nitrogen (BUN) and creatinine, and reduced renal expressions of neutrophil gelatinase-associated lipocalin (NGAL). The combination of PPD and MFR furtherly attenuated AKI with significantly decreased histological scores (p = 0.037) and reduced NGAL expressions (p = 0.0002) as compared with the MFR group. Moreover, MFR + PPD group had a significantly higher survival rate than that in the MFR and the PPD groups (p < 0.05, respectively). CONCLUSION: The use of PPD at the onset of compression release is beneficial for renal protection and survival outcome in a rabbit model of CI.
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Authors | Xian-Long Zhou, Shao-Zhou Ni, Dan Xiong, Xue-Qi Cheng, Peng Xu, Yan Zhao |
Journal | Scandinavian journal of trauma, resuscitation and emergency medicine
(Scand J Trauma Resusc Emerg Med)
Vol. 27
Issue 1
Pg. 68
(Jul 18 2019)
ISSN: 1757-7241 [Electronic] England |
PMID | 31319855
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Acute Kidney Injury
(etiology, mortality, therapy)
- Animals
- Biomarkers
(blood)
- Blood Urea Nitrogen
- Creatinine
(blood)
- Crush Injuries
(complications)
- Disease Models, Animal
- Fluid Therapy
(methods)
- Male
- Rabbits
- Renal Replacement Therapy
(methods)
- Resuscitation
(methods)
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