Abstract |
Background: Dynamic lung hyperinflation (DLH) following metronome-paced incremental hyperventilation (MPIH) was reported to be useful for assessment of pathophysiological impairment in patients with chronic obstructive pulmonary disease ( COPD), and the effects of tiotropium and olodaterol on DLH following MPIH have not been reported. Methods: Treatment consisted of administration of tiotropium/olodaterol 5/5 μg inhalation solution (2.5/2.5 μg per actuation) using a soft-mist inhaler once a day. We compared outcomes before and after 8 weeks of treatment. The primary outcome was defined as a decrease in inspiratory capacity (IC) from rest by MPIH, which is an index of DLH. The secondary outcomes were COPD assessment test (CAT), forced expiratory volume in 1 s (FEV1), and 6-min walking distance (6MWD). In addition, we investigated whether there were correlations between changes with treatment in DLH and FEV1, 6MWD, and dyspnea. Results: Thirty-three of the 38 registered patients completed this study. Most of these 33 patients had mild to moderate COPD. Decreasing IC by MPIH was significantly reduced by treatment for 8 weeks, with a mean change of about -0.11 to -0.13 mL (P <0.05). In addition, CAT score, FEV1, and 6MWD improved with treatment (P <0.05). There were no significant correlations between changes in DLH, FEV1, 6MWD, or dyspnea with treatment. Conclusions: The results of this study showed that the combination of tiotropium and olodaterol is effective for improvement of DLH following hyperventilation.
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Authors | Shohei Kawachi, Keisaku Fujimoto |
Journal | International journal of chronic obstructive pulmonary disease
(Int J Chron Obstruct Pulmon Dis)
Vol. 14
Pg. 1167-1176
( 2019)
ISSN: 1178-2005 [Electronic] New Zealand |
PMID | 31213796
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Video-Audio Media)
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Chemical References |
- Adrenergic beta-2 Receptor Agonists
- Benzoxazines
- Bronchodilator Agents
- Drug Combinations
- Muscarinic Antagonists
- tiotropium-olodaterol
- Tiotropium Bromide
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Topics |
- Administration, Inhalation
- Adrenergic beta-2 Receptor Agonists
(administration & dosage, adverse effects)
- Aged
- Benzoxazines
(administration & dosage, adverse effects)
- Bronchodilator Agents
(administration & dosage, adverse effects)
- Drug Combinations
- Dyspnea
(diagnosis, drug therapy, physiopathology)
- Exercise Tolerance
- Female
- Forced Expiratory Volume
- Humans
- Hyperventilation
(diagnosis, physiopathology)
- Japan
- Lung
(drug effects, physiopathology)
- Male
- Muscarinic Antagonists
(administration & dosage, adverse effects)
- Prospective Studies
- Pulmonary Disease, Chronic Obstructive
(diagnosis, drug therapy, physiopathology)
- Recovery of Function
- Time Factors
- Tiotropium Bromide
(administration & dosage, adverse effects)
- Treatment Outcome
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