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Angioimmunoblastic T-cell lymphoma and myelodysplastic syndrome with mutations in TET2, DNMT3 and CUX1 - azacitidine induces only lymphoma remission.

AuthorsMagnus Tobiasson, Tatjana Pandzic, Lucia Cavelier, Birgitta Sander, Björn Engelbrekt Wahlin
JournalLeukemia & lymphoma (Leuk Lymphoma) Vol. 60 Issue 13 Pg. 3316-3319 (12 2019) ISSN: 1029-2403 [Electronic] United States
PMID31204875 (Publication Type: Case Reports, Letter)
Chemical References
  • Antimetabolites, Antineoplastic
  • CUX1 protein, human
  • DNA-Binding Proteins
  • DNMT3A protein, human
  • Homeodomain Proteins
  • Proto-Oncogene Proteins
  • Repressor Proteins
  • Transcription Factors
  • Vincristine
  • Doxorubicin
  • Cyclophosphamide
  • Dioxygenases
  • TET2 protein, human
  • DNA (Cytosine-5-)-Methyltransferases
  • DNA Methyltransferase 3A
  • Azacitidine
  • Prednisone
Topics
  • Aged, 80 and over
  • Antimetabolites, Antineoplastic (pharmacology, therapeutic use)
  • Antineoplastic Combined Chemotherapy Protocols (pharmacology, therapeutic use)
  • Azacitidine (pharmacology, therapeutic use)
  • Bone Marrow (drug effects, pathology)
  • Cyclophosphamide (pharmacology, therapeutic use)
  • DNA (Cytosine-5-)-Methyltransferases (genetics)
  • DNA Methylation (drug effects)
  • DNA Methyltransferase 3A
  • DNA-Binding Proteins (genetics)
  • Dioxygenases
  • Doxorubicin (pharmacology, therapeutic use)
  • Drug Resistance, Neoplasm (genetics)
  • Female
  • Homeodomain Proteins (genetics)
  • Humans
  • Immunoblastic Lymphadenopathy (diagnosis, drug therapy, genetics)
  • Lymph Nodes (drug effects, pathology)
  • Lymphoma, T-Cell (diagnosis, drug therapy, genetics)
  • Mutation
  • Myelodysplastic Syndromes (drug therapy, genetics)
  • Prednisone (pharmacology, therapeutic use)
  • Proto-Oncogene Proteins (genetics)
  • Repressor Proteins (genetics)
  • Transcription Factors (genetics)
  • Treatment Outcome
  • Vincristine (pharmacology, therapeutic use)

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