Alcohol Drinking and Bladder Cancer Risk From a Pooled Analysis of Ten Cohort Studies in Japan.

Abstract

BACKGROUND:

The association of alcohol drinking with bladder cancer risk remains unclear in East Asian populations. Aldehyde dehydrogenase 2 (ALDH2) enzyme oxidizes alcohol-metabolized carcinogenic acetaldehyde into acetate. It is well known that the inactive ALDH2 carriers, specific to East Asian populations, have an increased risk of several cancer types because of increased exposure to acetaldehyde after alcohol consumption. The aim of this study was to examine the association between alcohol drinking and bladder cancer risk using data from ten population-based prospective cohort studies in Japan, where approximately 40% of the population has inactive ALDH2 enzyme.

METHODS:

We analyzed 340,497 Japanese participants with average follow-up of 13.4 years. The association between alcohol drinking and bladder cancer risk was evaluated using Cox regression models within each study, and random-effects models were used to estimate pooled hazard ratios (HRs) with corresponding 95% confidence intervals (CIs).

RESULTS:

During 4,729,071 person-years, 936 men and 325 women were newly diagnosed with bladder cancer. Our results showed no evidence of significant association between alcohol drinking and bladder cancer risk even among men who consumed alcohol of ≥69 g/week, with HR of 1.02 (95% CI, 0.79-1.33). The null result was observed consistently among women.

CONCLUSIONS:

Our findings do not support an association between alcohol drinking and bladder cancer risk in the Japanese, at least without consideration of the polymorphisms of alcohol-metabolizing enzymes.

• Authors: Hiroyuki Masaoka, Keitaro Matsuo, Isao Oze, Hidemi Ito, Mariko Naito, Keiko Wada, Chisato Nagata, Tomio Nakayama, Yuri Kitamura, Atsuko Sadakane, Akiko Tamakoshi, Ichiro Tsuji, Yumi Sugawara, Norie Sawada, Tetsuya Mizoue, Manami Inoue, Keitaro Tanaka, Shoichiro Tsugane, Taichi Shimazu
• Journal: Journal of epidemiology (J Epidemiol) Vol. 30 Issue 7 Pg. 309-313 (Jul 07 2020) ISSN: 1349-9092 [Electronic] Japan
• PMID: 31204364 (Publication Type: Journal Article)

Chemical References

• Alcohol Dehydrogenase
• ALDH2 protein, human
• Aldehyde Dehydrogenase
• Aldehyde Dehydrogenase, Mitochondrial

Topics

• Adult
• Alcohol Dehydrogenase (genetics)
• Alcohol Drinking (adverse effects, epidemiology)
• Aldehyde Dehydrogenase (genetics)
• Aldehyde Dehydrogenase, Mitochondrial (genetics, metabolism)
• Asian People (genetics)
• Female
• Humans
• Japan (epidemiology)
• Male
• Middle Aged
• Polymerase Chain Reaction
• Polymorphism, Genetic
• Prospective Studies
• Urinary Bladder Neoplasms (epidemiology, etiology)