Abstract | PURPOSE OF REVIEW:
Complement system dysfunction in terms of upregulation, downregulation, or dysregulation can create an imbalance of both host defense and inflammatory response leading to autoimmunity. In this review, we aimed at describing the role of complement system in host defense to inflection and in autoimmunity starting from the evidence from primary and secondary complement system deficiencies. RECENT FINDINGS: SUMMARY: The relationship between the complement system and autoimmunity appears paradoxical as both the deficiency and the activation contribute to inducing autoimmune diseases. In these conditions, the presence of complement deposition in affected tissues, decreased levels of complement proteins, and high levels of complement activation fragments in the blood and vessels have been documented.
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Authors | Paola Conigliaro, Paola Triggianese, Eleonora Ballanti, Carlo Perricone, Roberto Perricone, Maria Sole Chimenti |
Journal | Current opinion in rheumatology
(Curr Opin Rheumatol)
Vol. 31
Issue 5
Pg. 532-541
(09 2019)
ISSN: 1531-6963 [Electronic] United States |
PMID | 31192812
(Publication Type: Journal Article, Review)
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Chemical References |
- Complement System Proteins
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Topics |
- Autoimmune Diseases
(etiology, immunology, metabolism)
- Autoimmunity
(immunology)
- Complement Activation
- Complement System Proteins
(immunology, metabolism)
- Humans
- Infections
(complications, immunology, metabolism)
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